An ever-increasing number of community-acquired as well as nosocomial infectious diseases emphasizes the critical need for understanding the molecular nature of host-bacteria interactions. My research projects address important issues in the molecular mechanisms of Pseudomonas aeruginosapathogenesis.
In particular, we are interested in the role of Pseudomonas elastase and host cell signaling mediator in bacterial colonization and onset of inflammatory responses. Our long-term objectives are:
a) to investigate the role of P. aeruginosa elastase (PE) as ligand and identify the host cell receptors involved in adhesion;
b) to map the hot cell signal transduction pathways responsible for PE-induced cytokines and chemokines expression;
c) to establish the role of bacterial products in epithelial paracellular permeability and pulmonary edema;
d) to determine the role of bacterial toxins in extravascular coagulation/fibrinolysis;
e) to develop novel liposomal formulations to improve conventional antibiotics efficacy while reducing their toxicity.
We utilize cell and molecular technology, tissue culture, and small animal models to pulmonary infection and inflammations. Information derived from these studies will enable us to develop new interventional strategies to prevent the onset of infection and reduce the host inflammatory response and tissue injury.
Department of Biology
Ali Azghani Ph.D.
The University of Texas at Tyler
Tyler, TX 75799