Azghani's Pulmonary Biomedical Research Laboratory


1.Curtis A. Clark, Lauren K. Thomas, and Ali O. Azghani. 2011. Inhibition of PKC attenuates Pseudomonas aeruginosa elastase-induced epithelial barrier disruption. Am. J. Respir. Cell Mol. 14 July 2011.

2. Azghani, Ali. 2010. The Central Dogma of Molecular Biology and the New Clinical Research Order. The Monitor, 24(1); 25-28.

3. Alipour M, Suntres ZE, Halwani M, Azghani AO, Omri A. 2009. Activity and interactions of liposomal antibiotics in presence of polyanions and sputum of patients with cystic fibrosis. PLoS One, 4(5):e5724.

4. Halwani M, Hebert S, Suntres ZE, Lafrenie RM, Azghani AO, Omri A. 2009. Bismuth-thiol incorporation enhances biological activities of liposomal tobramycin against bacterial biofilm and quorum sensing molecules production by Pseudomonas aeruginosa. Int J Pharm. 2009 May 21;373(1-2):141-6.

5. Halwani, M, B. Yebio1, Z. E. Suntres, M. Alipour, A. O. Azghani, and A. Omri1, 2008.
Co-encapsulation of gallium with gentamicin in liposomes enhances antimicrobial activity of gentamicin against Pseudomonas aeruginosa. Journal of Antimicrobial Chemotherapy 62(6):1291-7, 2008.

6. Halwani, M, Shanna Blomme , Zacharias E. Suntres, Misagh Alipour, Ali O. Azghani, Aseem Kumar, Abdelwahab Omri. 2008. Liposomal Bismuth-Ethanedithiol Formulation Enhances Antimicrobial Activity of Tobramycin. International Journal of Pharmaceutics, 2008, 358(1-2): 254-63, 2008.

7. Idell S, Azghani A, Chen S, Koenig K, Mazar A, Kodandapani L, Bdeir K, Cines D, Kulikovskaya I, Allen T. 2007. Intrapleural low-molecular-weight urokinase or tissue plasminogen activator versus single-chain urokinase in tetracycline-induced pleural loculation in rabbits. Exp Lung Res. 33(8):419-40, 2007.

8. Yarlagadda, B, N. Subramanian, and A. Azghani, 2007. Artificial Neural Network-Based Estimation for Pseudomonas aeruginosa Experiments. IEEE Proceedings, 1-4244, 133- 137. 2007

9. Alipour Mr, Zacharias E. Suntres, Aseem Kumar, Marina Ulinova, Ali O. Azghani and Abdelwahab Omri. 2007. Antimicrobial Properties of Liposomal Aminoglycosides. Journal of Antimicrobial Chemotherapy.

10. Steven Idell, Timothy Allen, Shande Chen, Kathy Koenig, Andrew Mazar and Ali Azghani. 2006. Intrapleural activation, processing, efficacy, and duration of protection of single-chain urokinase in evolving tetracycline-induced pleural injury in rabbits. Am J Physiol Lung Cell Mol Physiol. 292:25-32, 2007.

11. Majed Halwani, Clement Mugabe, Ali O. Azghani, Robert M. Lafrenie, Aseem Kumar and Abdelwahab Omri 2007. Bactericidal Efficacy of Liposomal-Aminoglycosides against Burkholderia cepacia. J Antimicrob Chemother. 60(4):760-9.10 | A z g h a n i

12. Mugabe C, Azghani AO, Omri A., 2007. Preparation and characterization of dehydration- rehydration vesicles loaded with aminoglycoside and macrolide antibiotics. Journal of Antimicrobial Chemotherapy, 60(4):760-9. 2007.

13. Morrow, D.M,, Tahereh Entezari-Zaher, John Romashko II, Ali O. Azghani, Mohammad Javdan, Luis Ulloa, Edmund J. Miller, and Lin L. Mantell. 2007. Antioxidants preserve macrophage phagocytosis of Pseudomonas aeruginosa during hyperoxia . Free Radical Biology and Medicine 42 (9), 2007.

14. Mugabe, M. Halwani, A. O. Azghani, R. M. Lafrenie, A. Omri. 2006. Mechanism of Enhanced Activity of Liposome-Entrapped Aminoglycosides against Resistant Strains of Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy. 6; 50: 2016-2022

15. Sachar, P., N. Subramanian, and A. Azghani, 2006. A Knowledge Base for Biological Experiments. Proceedings of the IEEE Sixth Annual Emerging Information Technology Conference, Dallas, TX.

16. Gavin Rukholm, Clement Mugabe, Ali O. Azghani, and Abdelwahab Omri. 2006.
Antibacterial activity of liposomal gentamicin against Pseudomonas aeruginosa : a time–kill study. International Journal of Antimicrobial Agents 27: 247–252

17. Clement Mugabe, Ali O. Azghani, Abdelwahab Omri. 2006. Preparation and Characterization of Dehydration-Rehydration Vesicles Loaded Aminoglycoside and Macrolide Antibiotics. Int. Journal of Pharmaceutics, 307: 244–250

18. Clement Mugabe, Ali O. Azghani, and Abdelwahab Omri, 2005. Liposome-Mediated Gentamicin Delivery: Development and Activity against Resistant Strains of Pseudomonas aeruginosa Isolated from Cystic Fibrosis Patients. Journal of Antimicrobial Chemotherapy, 55, 269-271.

19. Shawn Rossi, Ali O. Azghani and Abdelwahab Omri, 2004. Antimicrobial efficacy of a new antibiotic-loaded poly (hydroxybutyric-co-hydroxyvalaric acid) controlled release system. Journal of Antimicrobial Chemotherapy, 54, 1013-1018.

20. Ashraf I. Zahra, Ali O. Azghani, Jason W. Baker, Siegfried Pueblitz, Anna Kurdowska, and Steven Idell. 2004. Experimental Acute Pseudomonas aeruginosa Pneumonia in Rabbits. The Medical Journal of Teaching Hospitals & Institutes, Egypt, 2004, 61, 49-60.

21. Azghani, A.O. and Rodolfo Amaro. 2003. Molecular basis of Pseudomonas inflammation and newtherapeutic interventions in cystic fibrosis. Recent Res. Devel. Infection & Immunity 1:387-403.

22. Azghani, A.O., Steven Idell, Manjeet Bains, and Robert E.W. Hancock. 2002. Pseudomonas aeruginosa outer membrane protein F is an adhesin in bacterial binding to lung epithelial cells in culture. Microbial Pathogenesis 33:109-14.

23. Azghani, A.O., Jason W. Baker, Sreerama Shetty, Ed J. Miller, and G. Jayarama Bhat. 2002. Pseudomonas aeruginosa elastase stimulates ERK signaling pathway and enhances IL-8 production by alveolar epithelial cells in culture. Inflammation Research 51 (10): 506 – 510.

24. Shetty, Sreerama, Usha R. Pendurthi, Prathap K. Shetty Halady, Ali O. Azghani, and Steven Idell. Urokinase induces its own expression in Beas2B lung epithelial cells. 2002. Am. J. Physiology, Lung Cellular and Molecular Physiology; 283:L319-L328.

25. Steven Idell M.D., Ph.D., Andrew Mazar Ph.D, Douglas Cines M.D., Graham Parry Ph.D., Susan Gawlak , Jose Juarez M.S. , Kathy Koenig, Ali Azghani Ph.D., Will Hadden D.V.M., Jerry McLarty Ph.D. and Edmund Miller Ph.D. 2002. Intrapleural Single-chain Urokinase Alone or Complexed to its Soluble Receptor Protects Against Pleural Adhesions in Tetracycline-induced Pleuritis in Rabbits. Am J Respir Crit Care Med 166: 920–926

26. Azghani, A.O., Miller E.J., and Peterson, B.T. 2000. Virulence factors from Pseudomonas aeruginosa increase lung epithelial permeability. Lung, 178: 261-269.
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27. Azghani, A.O. and T.F. Bedinghaus, T.F. and Klein, R. 2000. Detection of Elastase from Pseudomonas aeruginosa in Sputum and its potential Role in Epithelial Permeability. Lung, 178:181-189.

28. Obiso, Jr., R.J., Azghani, A.O., and Wilkins, T.D. 1997. Bacteriodes fragilis Disrupts the tight junctions of epithelial cells lines. Infection & Immunity. 65:1431-1439.

29. Azghani, A.O. 1996. Pseudomonas aeruginosa and epithelial permeability: role of virulence factors, elastase and exotoxin A. Am. J. Res. Cell & Ml. Biol. 15:132-140.

30. Azghani, A.O., Williams , I.F., Holiday, D.B., and Johnson, A. R., 1995. A beta-linked mannan inhibits adherence of Pseudomonas aeruginosa to human lung epithelial cells. Glycobiology, 5:39-44.

31. Azghani, A.O., Gray, L.T., and Johnson, A.R., 1993. Bacterial Protease perturbs paracellular barrier functions of transporting epithelium monolayers in culture. Infection & Immunity. 61: 2681- 2686.

32. Azghani, A.O., Kondepudi, A.Y., and Johnson, A.R. 1992. Interaction of Pseudomonas aeruginosa with human lung fibroblasts: role of bacterial elastase. Am. J. Respir. Cell and Mol. Biol. 6: 652-657.

33. Peterson, B.T., Collins, M.L., Gray, L.D., and Azghani, A.O., 1992. Aerosolized Pseudomonas elastase and lung fluid balance in anesthetized sheep. J. Appl. Physiology 72: 1927-1933.

34. Azghani, A.O., Connelly, J.C., Peterson, B. T., Gray, L.D., Collins, M.L., and Johnson, A.R., 1990. Effects of Pseudomonas aeruginosa elastase on alveolar epithelial permeability in guinea pigs. Infection & Immunity. 58: 433-438.

35. Garcia, Joe G.N., Azghani, A.O., Callahan, K.S., and Johnson, A.R. 1988. Effects of platelet activating factor on leukocyte-endothelial cell interactions. Thromb. Res. 51: 83- 96.

36. Azghani, A.O. and Fuerst, R., 1988. Studies of antibiotic resistant mutants of Bacteroides fragilis obtained by Cs-137 ionizing radiation. J. Ind. Microbiol. 3: 299-304.

37. Azghani, A.O. and Fuerst, R., 1982. Effects of gamma irradiation on Pseudomonas aeruginosa antibiotic susceptibility. Dev. Ind. Microbiol. 123: 579-585.


1. Azghani, A.O. and Curtis Clark. 2011. Bacterial Infection Process: An overview. Infection and Immunity.

2. Alipour M, Zacharias E. Suntres, Ali O. Azghani, and Abdlewahab Omri. 2008. Pulmonary infection in Cystic Fibrosis: Role of quorum-sensing. Recent Development in Signal Transduction Research, 2008, Editors; CV Ramana, Richard I. Enelow and Aseem Kumar.

3. Omri, M.L Anderson, C. Mugabe, Z. Suntres, M. R. Mozafari, and A. Azghani. 2007. Artificial implants–new developments and associated problems in nanomaterials and nanosystems for biomedical applications, Springer, 2007, Volume editor: M.Reza Mozafari

4. Azghani, A.O. and Rodolfo Amaro. 2003. Molecular basis of Pseudomonas inflammation and new therapeutic interventions in cystic fibrosis. Infection & Immunity 1:387- 403; Transworld Research Network.

5. Hector, J., Azghani, A.O., and Johnson, A.R. 1993. Genetic regulations of elastase in P. aeruginosa, pp. 145-162. In “Microbial Pathogenesis and Immunity,” edited by M. Campa et al, Plenum Press, New York.
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